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Thymosin Alpha-1

Thymosin Alpha-1

$120.00

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Processing time is 8–21 calendar days.

Thymosin Alpha-1 lyophilised research peptide in Australia, supplied for in-vitro laboratory investigation. Synthetic 28-amino-acid N-terminally acetylated polypeptide derived from prothymosin alpha (sequence Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN). ≥99% purity by HPLC, third-party Certificate of Analysis available. Dispatched within 1-3 business days. Research use only. Not for human consumption, therapeutic use, or diagnostic application.

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Product details

Research Context

Thymosin Alpha-1 (Tα1, thymalfasin) is a 28-amino-acid N-terminally acetylated polypeptide derived from prothymosin alpha by proteolytic processing. The mature peptide is heavily acidic, dominated by aspartate and glutamate residues, and carries a critical N-alpha acetyl group on the N-terminal serine. This acetyl modification is essential for biological activity and confers protection against aminopeptidase degradation.

Preclinical literature has examined Tα1 as an immunomodulatory reference compound in studies of dendritic cell maturation, Toll-like receptor 2 and 9 signalling, T-cell differentiation, natural killer cell activation, and host responses in viral hepatitis and oncology models. It is widely cited in immunology benchmark studies.

Chemistry & Structural Modification

Linear 28-residue acetylated peptide with sequence Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH. The N-alpha acetyl group (mass increment 42 Da vs the non-acetylated form) is a critical COA verification parameter.

  • Molecular formula: C129H215N33O55
  • Molecular weight: 3108.31 g/mol
  • CAS number: 62304-98-7; PubChem CID 16130571

Lyophilisation & Stability

Supplied as a lyophilised white-to-off-white powder in a sealed glass vial. Lyophilisation removes residual water that drives amide-bond hydrolysis and aspartate-derived succinimide formation, both relevant for acidic peptides of this length. The dry-state form is stable for extended periods provided the vial is kept sealed, cold, and protected from light. Once opened or reconstituted, stability decreases substantially and the material should be handled accordingly.

Storage

Store lyophilised vial at 2 to 8°C, protected from light. (Long-term storage at −20°C is standard practice.)

Reconstituted solution: 2 to 8°C, used within 14 to 30 days. Avoid repeated freeze–thaw cycles.

Quality & Documentation

  • Purity: ≥99% by HPLC
  • Certificate of Analysis (COA): published on our COA page.

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