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Tirzepatide

Tirzepatide

Price range: $65.00 through $220.00

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Tirzepatide lyophilised research peptide in Australia, supplied for in-vitro laboratory investigation. Synthetic 39-residue lipidated polypeptide investigated as a dual GIP and GLP-1 receptor agonist in preclinical metabolic research. ≥99% purity by HPLC, third-party Certificate of Analysis available. Dispatched within 1-3 business days. Research use only. Not for human consumption, therapeutic use, or diagnostic application.

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Product details

Research Context

Tirzepatide is a synthetic, lipidated 39-amino-acid polypeptide developed as a dual agonist at the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The backbone is derived from the native GIP sequence with substitutions at positions 2 and 13 (aminoisobutyric acid) and a fatty-acid side chain on a central lysine, modifications that together extend plasma stability and reduce DPP-4 mediated proteolysis in laboratory assay systems.

This lyophilised material is supplied exclusively for in-vitro laboratory and scientific investigation. Preclinical studies have examined receptor binding affinity at GIPR and GLP-1R, downstream cAMP signalling, β-arrestin recruitment, and metabolic-pathway readouts in cultured cells and rodent tissue. No therapeutic, performance, or human-use claims are made or implied.

Chemistry & Structural Modification

Tirzepatide contains a 39-residue backbone with two aminoisobutyric acid (Aib) residues and a C20 fatty-diacid side chain linked through a γ-glutamyl-AEEA-AEEA spacer to a central lysine. The lipid conjugate drives reversible albumin binding in plasma-stability assays.

  • Molecular formula: C225H348N48O68
  • Molecular weight: 4813.45 g/mol
  • CAS number: 2023788-19-2; PubChem CID 166567236

Lyophilisation & Stability

Each vial is supplied as a sterile lyophilised solid. Lyophilisation removes bulk water while preserving the lipidated peptide in a low-moisture, non-reactive matrix, which is critical for compounds bearing long-chain fatty-acid conjugates that are susceptible to hydrolysis in aqueous solution. Sealed vials remain stable for extended periods when stored cold and protected from light and moisture.

Storage

Store lyophilised vial at 2 to 8°C, protected from light. (Long-term storage at −20°C is standard practice.)

Reconstituted solution: 2 to 8°C, used within 14 to 30 days. Avoid repeated freeze-thaw cycles.

Quality & Documentation

  • Purity: ≥99% by HPLC
  • Certificate of Analysis (COA): published on our COA page.

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