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MOTS-c

MOTS-c

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MOTS-c lyophilised research peptide in Australia, supplied for in-vitro laboratory investigation. Mitochondrial-derived peptide encoded within the mitochondrial 12S ribosomal RNA gene (sequence MRWQEMGYIFYPRKLR). ≥99% purity by HPLC, third-party Certificate of Analysis available. Dispatched within 1-3 business days. Research use only. Not for human consumption, therapeutic use, or diagnostic application.

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Product details

Research Context

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S ribosomal RNA gene, first described in 2015. Unlike the vast majority of human peptides, which are encoded by nuclear DNA, MOTS-c is one of a small class of MDPs encoded directly by the mitochondrial genome. The class also includes the humanin family and the small humanin-like peptides (SHLP1 to SHLP6). MOTS-c is detectable in plasma, declines with age, and has become the prototypical mitokine in retrograde mitochondrial-to-nuclear signalling research.

Preclinical literature has examined MOTS-c as a tool compound for investigating mitochondrial metabolism, AMPK-mediated metabolic flexibility, insulin sensitivity in skeletal muscle and adipose tissue models, and exercise-mimetic signalling pathways. It is widely cited in studies of cellular energy homeostasis and ageing biology.

Chemistry & Structural Modification

Linear 16-residue peptide with sequence Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR). Contains two internal methionine residues, making it susceptible to oxidation under suboptimal storage conditions.

  • Molecular formula: C101H152N28O22S2
  • Molecular weight: 2174.6 g/mol
  • CAS number: 1627580-64-6; PubChem CID 146675088

Lyophilisation & Stability

Supplied as a lyophilised white-to-off-white powder in a sealed glass vial under inert atmosphere. Lyophilisation is particularly important for this sequence because the two internal methionine residues are vulnerable to oxidation to methionine sulfoxide on prolonged exposure to moisture and oxygen. The dry-state form is stable for extended periods provided the vial is kept sealed, cold, and protected from light. Reconstituted material should be handled quickly and kept cold.

Storage

Store lyophilised vial at 2 to 8°C, protected from light. (Long-term storage at −20°C is standard practice.)

Reconstituted solution: 2 to 8°C, used within 14 to 30 days. Avoid repeated freeze-thaw cycles.

Quality & Documentation

  • Purity: ≥99% by HPLC
  • Certificate of Analysis (COA): published on our COA page.

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