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Melanotan-1

Melanotan-1

$55.00

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Melanotan-1 lyophilised research peptide in Australia, supplied for in-vitro laboratory investigation. Synthetic tridecapeptide analogue of α-melanocyte-stimulating hormone (sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂). ≥99% purity by HPLC, third-party Certificate of Analysis available. Dispatched within 1-3 business days. Research use only. Not for human consumption, therapeutic use, or diagnostic application.

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Product details

Research Context

Melanotan-1 (also designated [Nle4, D-Phe7]-α-MSH or NDP-α-MSH) is a synthetic tridecapeptide analogue of the endogenous hormone α-melanocyte-stimulating hormone (α-MSH). Two substitutions distinguish it from native α-MSH: norleucine (Nle) at position 4 and D-phenylalanine at position 7. Together, these substitutions confer resistance to enzymatic degradation and elevated binding affinity at the melanocortin-1 receptor (MC1R) relative to the parent hormone in cell-based assay systems.

This lyophilised material is supplied exclusively for in-vitro laboratory and scientific investigation. Preclinical studies have examined Melanotan-1 in the context of MC1R, MC3R, MC4R, and MC5R binding profiles, adenylyl-cyclase activation in cultured melanocytes, and pigmentation-pathway readouts in cell lines. No therapeutic, performance, or human-use claims are made or implied.

Chemistry & Structural Modification

Melanotan-1 is a linear tridecapeptide with the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. The N-terminus is acetylated and the C-terminus is amidated, modifications standard for melanocortin agonist analogues that block exopeptidase degradation. The conserved His-D-Phe-Arg-Trp motif is the melanocortin “active site” responsible for receptor engagement.

  • Molecular formula: C78H111N21O19
  • Molecular weight: 1646.85 g/mol
  • CAS number: 75921-69-6; PubChem CID 16154396

Lyophilisation & Stability

Each vial is supplied as a sterile lyophilised solid. Lyophilisation removes bulk water and yields a stable, low-moisture cake that limits oxidative and hydrolytic degradation of the tryptophan side chain. (Norleucine at position 4 already replaces alpha-MSH’s oxidation-prone methionine, so the backbone itself is inherently oxidation-resistant.) Sealed vials remain stable for extended periods when stored cold, dry, and protected from light.

Storage

Store lyophilised vial at 2 to 8°C, protected from light. (Long-term storage at −20°C is standard practice.)

Reconstituted solution: 2 to 8°C, used within 14 to 30 days. Avoid repeated freeze–thaw cycles.

Quality & Documentation

  • Purity: ≥99% by HPLC
  • Certificate of Analysis (COA): published on our COA page.

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