Back to Shop
KPV

KPV

$55.00

In stock

Processing time is 1–2 business days.

KPV lyophilised research peptide in Australia, supplied for in-vitro laboratory investigation. Synthetic tripeptide corresponding to residues 11-13 of α-melanocyte-stimulating hormone (sequence Lys-Pro-Val). ≥99% purity by HPLC, third-party Certificate of Analysis available. Dispatched within 1-3 business days. Research use only. Not for human consumption, therapeutic use, or diagnostic application.

Buy more, Save more

Buy 1 Standard —
Buy 2 Save 5% —
Buy 3 Save 10% —
Buy 4 Save 15% —
Product details

Research Context

KPV is the synthetic tripeptide L-lysyl-L-prolyl-L-valine (Lys-Pro-Val), corresponding to residues 11 to 13 of alpha-melanocyte-stimulating hormone (alpha-MSH). The full alpha-MSH peptide is a 13-residue post-translational cleavage product of pro-opiomelanocortin (POMC) and acts through the melanocortin receptor family. Carboxy-terminal tripeptide fragments of alpha-MSH, including KPV, were characterised in early melanocortin structure-activity studies as retaining a subset of the parent hormone’s biological signatures despite lacking the melanocortin receptor-binding pharmacophore at the N-terminus.

Preclinical studies have examined KPV in models of mucosal inflammation, intestinal-epithelial signalling, NF-kappaB pathway modulation, and cellular responses associated with the alpha-MSH C-terminal motif. Patents covering antipyretic and anti-inflammatory compositions of Lys-Pro-Val were filed in the early 1990s, and the tripeptide has remained an active reference compound in melanocortin and inflammation research.

Chemistry & Structural Modification

KPV is an unmodified linear tripeptide of three standard L-amino acids, joined by conventional alpha-peptide bonds, with free N-terminal amine and C-terminal carboxylic acid (H-Lys-Pro-Val-OH). No protecting groups, lipidation, or cyclisation.

  • Sequence: Lys-Pro-Val (3 residues)
  • Molecular formula: C16H30N4O4
  • Molecular weight: 342.43 g/mol
  • CAS number: 67727-97-3; PubChem CID 125672

Lyophilisation & Stability

KPV is supplied as a lyophilised white powder, sealed under controlled conditions. Lyophilisation removes residual moisture that would otherwise promote slow peptide-bond hydrolysis during long-term storage. As a short, unmodified linear tripeptide with no cysteine, methionine, or tryptophan, KPV has no obvious oxidation-prone residues, but standard cold-and-dry storage remains best practice. Sealed vials kept cold and dry retain ≥99% potency well within the labelled shelf life.

Storage

Store lyophilised vial at 2 to 8°C, protected from light. (Long-term storage at −20°C is standard practice.)

Reconstituted solution: 2 to 8°C, used within 14 to 30 days. Avoid repeated freeze–thaw cycles.

Quality & Documentation

  • Purity: ≥99% by HPLC
  • Certificate of Analysis (COA): published on our COA page.

Related products